Researcher: Priness Jane T. Mendoza, June 2019
Adviser: Aaron Carl V. Tejano
Hyperuricemia is caused by high levels of uric acid in body, which leads into gout. Nephrotoxicity is one of the causes of the renal problems and as reported it is a lifetime risk among the countries such as Europe, America, and Asia including the Philippines. Potassium bromate (KBrO3) has been conventionally used as a flour improver and as food additive which is an oxidizer although it can elevate serum uric acid and promotes nephrotoxicity. Ziziphus talanai has been found out to contain different secondary metabolites that are essential for nephroprotection and antioxidant property. Twelve mice were subjected to administration of treatments for 14 days. Treatments were administered via intraperitoneal and intragavage technique. To is treated with water alone of 1ml/20g body weight. Tis treated with 200mg/kg KBr03 alone. T+ is treated with 200mg/kg ascorbic acid. Tl is treated with 1000mg/kg of ethanol leaf extract of Ziziphus talanai. Body weight and kidney weight of mice showed no changes after 14 days. The plant extract does not reduce blood uric acid in the mice but showed protective effects of the histoarchitecture of mice kidney tissue. It can be stated that the plant extract presents nephroprotective but not hypouricemic potential.
Keywords: Ziziphus talanai, hypouricemic, nephrotoxicity, potassium bromate, histoarchitecture
Mendoza, P. J. T. (2019). Hypouricemic and nephroprotective potential of ethanol leaf extract of Balakat tree (Ziziphus talanai (Blanco) Merr.) against potassium bromate-induced toxicity in male albino mice [Unpublished undergraduate thesis].