Researcher: Ciara Mae F. Liboon, May, 2018 Adviser: Lourdes Fatima S. David, M.Sc.
Peptic Ulcer Disease, a widely known disease can develop due to stress, smoking, nutritional deficiencies and alcohol which contribute greatly in inducing lacerations and hemorrhagic streaks in stomach resulting to ulcer. Omeprazole is a commercial drug used to treat ulcers, but recent studies showed relapses and side effects of this drug. Preliminary phytochemical analysis indicated the presence of bioactive compounds with Antiulcerogenic potentials in Balakat tree (Ziziphus talanai), and other genus of Ziziphus spp. which are traditionally used to treat ulcers. 12 male albino rats were divided into four groups with three rats each. Treatments were administered via oral gavage technique for 1 day. To negative control (distilled water) at a dose level of 75ml/150g(bw). T-negative control (ethanol) at a dosage level of 40ml/150g (bw). T+ positive control group (omeprazole) at a dosage of .40ml/150g (bw). T1 (Z. talanai ethanol leaf extract) at a dosage of .40ml/150g (bw). Macrosopic and histopathological observations revealed that T- (ethanol) rats showed lacerations and hemorrhagic streaks indicating the presence of ulcer. T+ (omeprazole) rats showed lesser lacerations and hemorrhagic streaks compared to T+. Tl (leaf extract) rats showed very few damaged cells but no lacerations and hemorrhagic streaks. Thus, the Z. talanai leaf extract mitigated the ulcerogenic effects of ethanol causing an improvement in the stomach induced with ulcer due to the flavonoids which possess antiulcerogenic potentials.
Keywords: Ziziphus talanai (Blanco) Merr., antiulcerogenic, necrotic lesions, leukocyte infiltration, ethanol
Liboon, C. M. F. (2018). Evaluation of antiulcerogenic potential of ethanol leaf extract of Balakat tree (Ziziphus talanai (Blanco) Merr.) against ethanol-induced ulcer in male albino rats (Ratus germinavicus) [Unpublished undergraduate thesis]. Mabalacat City College.