Researcher: Valerio, Gracia May C. June 2019
Adviser: Lourdes Fatima S. David M.Sc.
ABSTRACT
PUD or Peptic Ulcer Disease, is a common disease in this generation because of the stress, smoking, nutritional deficiencies and drinking alcohols which contribute extremely in inducing lacerations and hemorrhagic streaks in stomach ensue to ulcer. Omeprazole is used in this study which is the common drug that is used for people who are suffering from this disease, but recent studies proved that Omeprazole showed relapses and side effects. Preliminary phytochemical analysis indicated the existence of bioactive compounds with Antiulcerogenic potentials in Balakat Tree (Ziziphus talanai), and other genus of Ziziphus spp. Which are traditionally used to treat ulcers. Fifteen (15) male albino rats were divided into five (5) groups with three (3) rats each. Treatments were administered via oral gavage technique for one (1) day. Negative control group 1 (Distilled water alone) at a dose level of 75/150g (body weight), Negative control group 2 (Ethanol alone) at a dosage level of .40/150g (bw), Positive control group (omeprazole) at a dosage of .40ml/150g (bw), T1 (Z. talanai Ethanol Bark Extract) and T2 (Z. talanai Ethanol Root Extract) at a dosage of 40/150g (b). On the histopathological and macroscopic observations revealed that T- (ethanol) rats has showed hemorrhagic streaks and laceration which explains that there is a presence of ulcer. T+ (omeprazole) rats showed spot ulcers compared to T-. T1 (Bark Extract) rats showed no lacerations and hemorrhagic streak same as the TO (distilled water alone). T2 (Root extract) rats showed a minimal red coloration, no lacerations and hemorrhagic streaks. So the Ziziphus talanai bark and root extract mitigated the ulcerogenic effects of ethanol causing an improvement in the stomach induced with ulcer due to the flavonoids which possess antiulcerogenic potentials.
Keywords: Ziziphus talanai (Blanco) Merr., antiulcerogenic, ethanol, laceration, flavonoids
Valerio, G. M. C. (2019). Evaluation of Antiulcerogenic Potential of Ethanol Bark and Roots of Balakat Tree (Ziziphus talanai (Blanco) Merr.) Against Ethanol-Induced Ulcer in Male Albino Rats (Ratus germinavicus), Mabalacat City College, Dolores, Mabalacat City, Pampanga. [Undergraduate thesis, Mabalacat City College].