Researcher: Maria Anabelle A. Samson, June 2019
Obesity tends to increase the bad cholesterol (LDL) and lower the good cholesterol (HDL) levels. Getting older also causes LDL cholesterol to rise and genetics may even play a major role in it. Numerous studies on Balakat tree (Ziziphius talanai (Blanco) Merr.) and its antioxidating potential were recognized. This study aims to evaluate the potential of ethanolic leaf extracts of Balakat tree (Ziziphus talanai (Blanco) Merr) in lowering cholesterol and reduction of Monosodium Glutamate Induced obesity on female albino rats. Simvastatin with 50 mg/kg of MSG was used as a positive control. Female albino rats shown to be decreasing not withstanding in body weight has a very small augmentation per week and is significantly at the last day of treatment. All rats from different treatments showed body weight reduction from Week 0 to Week 2. The results of Intrascapular and Visceral fat weight showed reduction with treatment of simvastatin, 400mg/kg and 800mg/kg of balakat extract. The results of serum lipid profile of rats treated with simvastatin, 400mg/kg and 800mg/kg of balakat extract exhibited reduction in the normal level of CHOL, TAG, HDL, LDL and VLDL.
Keywords: Anti-cholesterol, Simvastatin, Monosodium Glutamate, Bad cholesterol, Good cholesterol, High fat diet, Lipid synthesis.
Samson, M. A. (2019). Anti-cholesterol and fat reduction potential of ethanol leaf extract of Balakat tree (Ziziphus talanai (Blanco) Merr.) against monosodium glutamate-induced obesity in female albino rats (Rattus sp.) [Unpublished undergraduate thesis]. Mabalacat City College