Researcher: Dela Jara, John Paolo Tomas. June 2019
Adviser: Aaron Carl V. Tejano
ABSTRACT
Copper (Cu) is necessary in functioning of living organisms (Michaluk and Kochman 2007, Roychoudhury et al. 2008, 2009, Uauy et al. 2008, Yunus et al. 2015).The widespread use of this metal in building materials and intrauterine contraceptive devices resulted in its adverse effects, including toxicity in testis (CDA 2013, Roychoudhury and Massanyi 2014, Zhang et al. 2012). Previous studies documented the reproductive potential of Balakat tree (Ziziphus talanai (Blanco) Merr.). Male albino rats were randomly grouped into five treatments. TO (2ml distilled water), T-(100mg/kg copper sulphate), T+(20mg/kg resveratrol and 100mg/kg copper sulphate), T1 (200mg/kg ethanol leaf extract of balakat tree), T2 (200mg/kg ethanol leaf extract of balakat tree and 100mg/kg copper sulphate) administered concurrently. There were no observable morphological changes in the body of the rats in each treatments. Rats treated with copper sulphate, resveratrol and balakat extract exhibit weight gain. Copper sulphate group shows proliferation of interstitial cells in response to low testosterone level and sperm immaturity. Water alone, resveratrol treated group, and balakat extract treated group show regular number and spacing of seminiferous tubule, with mild interstitial tissue loosening and normal sperm maturation. The results show that the ethanol leaf extract of balakat tree (Ziziphus talanai (Blanco) Merr.) has a phytoconstituents that can be stated as testiculoprotective.
Keywords: Testiculoprotective, Copper sulphate, Balakat tree, testicular injury
Dela J. & Tomas, J. P. (JUNE 2019). POTENTIAL OF ETHANOL LEAF EXTRACT OF BALAKAT TREE (Ziziphus talanai (Blanco) Merr.) AGAINST COPPER INDUCED TESTICULAR INJURY IN MALE ALBINO RATS, MABALACAT CITY COLLEGE, DOLORES, MABALACAT CITY, PAMPANGA. [Undergraduate thesis, Mabalacat City College].