Researcher: Santos, Jewel Mae G. June 2019
Adviser: Sarah Joy D. Dizon, M. Sc.
ABSTRACT
Diarrheal disease is a major health concern that is one of the leading causes of death in developing countries especially in children. It is usually acquired through fecal-oral transmission, or by coming into contact with contaminated material. The phytoconstituents of the balakat tree (Ziziphus talanai (Blanco) Merr.) leaves, a plant endemic to the Philippines, include triterpenes, alkaloids, glycosides, sterols, flavonoids, tannins, saponins, essential oils, anthraquinones, steroids, coumarins, and anthrones, some of which are known to protect against intestinal damage and provide inhibitory activity against the excretion of fluids and electrolytes. The study employed 30 mice distributed in 5 groups. T-received castor oil (0.5ml/animal) with distilled water (10ml/kg); T+ received castor oil (0.5ml/animal) with loperamide (3mg/kg); T1 received castor oil (0.5ml/animal) with ethanol leaf extract at the dosage of 100mg/kg; T2 received castor oil (0.5ml/animal) with ethanol leaf extract at the dosage of 200mg/kg: 13 received castor oil (0.5ml/animal) with ethanol leaf extract at the dosage of 400mg/kg. Administration of T- resulted in frequent excretion. Administration of different dosages of ethanol leaf extract revealed that they did not yield statistically significant on the onset of diarrhea (p=0.7181), Total number of feces (p=0.7179) and Distance travelled by charcoal (p=0.6501). Though the values did not yield statistically significant (p>0.05), the treatments did show signs of diarrheal inhibition, with the 200mg/kg dose showing a percentage of inhibition of 23.23% in comparison to the 55.56% of the loperamide. It can be stated that the ethanol leaf extract of 2. talanai possesses anti-diarrheal potential.
Keywords:ย Diarrhea, Ziziphus talanai, castor oil, anti-diarrheal, gastrointestinal motility
Santos, J. M. G. (2019). ANTI-DIARRHEAL POTENTIAL OF BALAKAT TREE (Ziziphus talanai (Blanco) Merr.) ETHANOLIC LEAF EXTRACT AGAINST CASTOR OIL-INDUCED DIARRHEA IN MICE (Mus musculus L.), Mabalacat City College, Dolores, Mabalacat City, Pampanga. [Undergraduate thesis, Mabalacat City College].