Researcher: Jenny Lou E. Pring, June 2018
Adviser: Sarah Joy Dizon
Abstract
Inflammation is common associated with diseases such as dermatitis, hepatitis, ulcerative colitis, arthritis and asthma. There are commercial drugs convenient for inflammation like ibuprofen, aspirin, diclofenac and etc. however most of these drugs are non-steroid which can cause obstructions in the body. Some of the effects of the non-steroid drugs (NSAID) include osteoporosis, epigastric distress, peptic ulceration and Cushing’s syndrome. To decipher the problem with non-steroid drugs, researchers were developing organic drugs to reduce the risk of the said effects of NSAID. Consequently, the anti-inflammatory potential of Ziziphus talanai was assessed using ethanol leaf extract administered orally to ICR mice. Inflammation was induced in both ears of mice models. The study has four different treatments, to using distilled water alone, T+ using diclofenac sodium as the standard drug for inflammation and the two balakat extracts with varying dosages, Tโ with 50mg/kg leaf extract and Tโ with 100mg/kg leaf extract. For the three hours of treatments, gathered data shows that To (distilled water) has the least percentage of edema inhibition with 1.94% followed by T+ (diclofenac sodium) with 27.48% then T2 (100mg/kg leaf extract) with 29.70% and the most effective agent was observed in Tโ (50mg/kg leaf extract) with 48.36% of edema inhibition. Statistical analysis using One-way ANOVA gives 0.0001 p value which means that all treatments have significant difference with each other thus rejecting the null hypothesis. The anti-inflammatory potential of Z. talanai may be due to the presence of organic compounds present in the leaf such as tannins, alkaloids, saponins and flavonoids. Several studies have shown anti-inflammatory effects can be a result of high phenols and flavonoids content of plants (Handa et al., 1992; Orhan et al., 2007).
Pring, J. L. E. (2018). Balakat (Ziziphus talanai (Blanco) Merr.) ethanolic leaf extracts against xylene-induced ear edema in Mus musculus L. ICR mice [Undergraduate thesis, Mabalacat City College].