Researcher: Glen, S. Nolasco, April 10, 2018
Adviser: Lourdes Fatima Sula-David, M.Sc.
Abstract
Ziziphus talanai an endemic species of plant located on the Philippines reported the presence of Flavoids and possessed neuroprotective potential in the cerebellar part of the mice brain. Thus, this study aimed to evaluate the neuroprotective potential of Z. talanai in mice. Total of 24 mice were distributed randomly in water alone, MSG alone, MSG+ L-taurine, Extract alone, MSG +25% extract, MSG +50% extract, MSG +75% extract and MSG + 100% extract. The results of test crawling along the rope showed that mice treated with MSG failed the test. However, mice treated with L-taurine 2 mice passed the test and the other failed. In the mice treated with extracts revealed that as the concentration of extract increases, mice that pass the test increase also; thus supported that extract possessed anxiolytic property. In the Y-maze test with p value of <0.0001, MSG treated group was significant to mice treated with extract alone extract alone, L-taurine, 50%, 75% and 100% extract. Interestingly, the water alone group was significant to the results of extract alone, 75% and 100% extract. These justified the memory enhancer property of extract. In the histopathological assessment, it showed that treated MSG congestion, exhibited hemorrhage, gliosis, vacuolation, neuronophagia, vasculitis, hyperplasia, pyknosis and karyorrhexis. Interestingly, histological ameriolation of the prefrontal and hippocampus increases as the concentration of the extract gets higher. Hence, the Z. talanai possessed neuroprotective potential due to its flavonoids.
Keywords: ziziphus talanai, flavonoids, neuroprotective, MSG, neuroprotective
Nolasco, G. S. (2018). Neuroprotective potential of ethanol leaf extract of Balakat tree (Ziziphus talanai (Blanco) Merr.) against monosodium glutamate-induced oxidative stress in male ICR mice (Mus musculus L.) [Undergraduate thesis, Mabalacat City College].